WebApr 10, 2024 · The emergence of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) revolutionized the treatment of advanced-stage non-small cell lung cancer (NSCLC). Detected in more than 50% of late-stage lung adenocarcinoma in Asian patients, the EGFR mutation was regarded as a golden mutation for Asians. However, … WebSep 11, 2024 · Wu, Y. L. et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): An open ...
Frontiers Profiling Oncogenic Germline Mutations in Unselected ...
WebJun 24, 2024 · For Asian patients with NSCLC and adenocarcinoma histology, the most common types of EGFR mutations include exon 19 deletions (Ex19del) and exon 21 (Ex21) L858R substitutions, accounting for 85% to 90% of all TK domain mutations. 3-5, 11 Other uncommon mutations or double mutations are reported in about 4% of patients. WebConclusion: PIONEER is the first prospective study to confirm high EGFR mutation frequency (51.4% overall) in tumors from Asian patients with adenocarcinoma. The … sovd thüringen
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WebSep 10, 2024 · According to research, certain ethnicities are more susceptible to EGFR mutations. People of Asian descent who develop non-small cell lung cancer (NSCLC) are almost 47% more likely to have … WebJan 21, 2024 · EGFR tyrosine kinase inhibitors (often shortened to EGFR TKI treatments) are a form of treatment for NSCLC called EGFR mutation-positive NSCLC. There are currently five EGFR TKI treatments available, which are categorized based on when they were developed. First-generation EGFR TKI treatments were developed first, followed by … WebMar 10, 2024 · Otherwise, the prevalence of somatic mutations in other commonly mutated cancer genes in Asian lung cancer patients including EGFR (44.6% (41/92) in patients with germline mutations vs. 46.7% (675 ... sovdwaer shop